Fresh analysis suggests that patients who come off blockbuster weight-loss injections like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who end conventional diet and exercise regimens.
Published data in a leading health publication points out that while obese people can lose substantial amounts of their body weight while on the medication, the mass is regained at an average rate of 0.8 kg per month once they quit.
"Users buying these medications need to be cognizant of the risk of fast weight regain when the treatment is stopped," cautioned lead investigator Dr. Susan Jebb.
That rate of regain suggests a return to pre-treatment mass within about a year and a half.
Weighing Treatments
The research, which reviewed 37 of studies involving thousands of patients, contrasted the results of the injectable medications with other pills.
Scientists note that people who shed pounds through lifestyle changes alone generally experience a less rapid weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Fast Regain
Experts suggest the mode of action of the drugs explains the amplified regain.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which moderates appetite.
"Sustained high doses of the hormone levels far above than normal might result in the body to generate a reduced amount of its own natural hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a nutrition expert.
"Discontinuation of this GLP-1 'fix' results in appetite is uncontrolled, making overeating far more likely."
A Chronic Disease?
Medical guidelines recommend the injections for people with obesity-related health risks, alongside recommended diet and exercise modifications.
Many experts contend that, due to the significant potential of weight regain, the therapy should be considered long-term.
This opinion is echoed by pharmaceutical companies, who say that the findings "emphasize the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Accounts
Individuals who have come off the jabs report a intense return of appetite.
"It felt as if a switch activating and you're instantly extremely hungry," recalled an individual.
This challenge is worsened if patients have not adopted permanent lifestyle or habit changes during treatment.
Widespread Use
Figures indicate that a significant number of adults in the UK have tried these injections in the past year, with desire being substantial.
- Adoption is higher among women than men.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
Finally, researchers caution that while the jabs are powerful agents for weight loss, they are not a permanent cure and lasting health benefits relies on ongoing behavioural support.
